Pain

Chronic Pain

    • Moderate to Severe Chronic Pain: 31 screened, 21 randomized over 5 weeks
    • Chronic low back pain: 27 screened, 23 randomized over 4 months
    • Chronic pain: 28 screened, 24 randomized over 3 months
    • Non-malignant, non neuropathic pain: 22 screened, 20 randomized in 2 months

Constipation

    • Opioid induced constipation (OIC): 14 screened, 8 randomized over 6 months
    • Opioid induced constipation (OIC): 8 screened, 5 randomized over 7 months
    • Chronic idiopathic constipation (CIC): 36 screened, 19 randomized over 8 months

Fibromyalgia

    • Fibromyalgia: 49 screened, 33 randomized over 7 months
    • Fibromyalgia: 33 screened, 22 randomized over 6 months
    • Fibromyalgia: 14 screened, 12 randomized over 2 months

Migraine

    • Menstrual migraine: 42 screened, 41 randomized over 3 months
    • Migraine: 30 screened, 26 randomized over 3 months
    • Episodic Migraine: 16 screened, 8 randomized over 2 months

Neuropathic Pain

    • Diabetic neuropathy (DPN): 27 screened, 19 randomized over 9 months
    • Diabetic neuropathy (DPN): 22 screened, 18 randomized over 4 months
    • Post herpetic neuralgia (PHN): 7 screened, 6 randomized over 3 months

Osteoarthritis

    • Osteoarthritis (OA): 26 screened, 12 randomized over 8 months
    • Osteoarthritis (OA): 14 screened, 8 randomized over 7 months
    • Osteoarthritis (OA): 13 screened, 7 randomized over 5 months