As clinical trials grow in scope and complexity, NeuroCog Trials (NCT) provides the scientific and operational clarity needed for optimal trial performance and accelerated drug development. With unparalleled experience in clinical outcomes and neurocognitive measurement, and a proven track record in supporting trial design, implementation, and evaluation, the company delivers expert guidance and data you can trust.

NCT has exceptional versatility and depth of expertise in psychiatry, neurology, neuropsychology, clinical psychology, cognitive neuroscience, clinical trials methodology, project management, technology development, and regulatory assurance. With an unwavering commitment to data integrity, the company’s work supports the scientific investigation of novel therapies and drives major improvements to the overall quality of clinical trials.

Download the NCT fact sheet.

eSolutions

NeuroCog Trials offers innovative technology that can be easily configured to meet the needs of any study to assess cognition, functioning, and symptoms in a wide range of clinical indications.

NCT Pathway
Allow your trial to reach its full potential with NCT Pathway, a dynamic eCOA platform easily configurable to meet the unique needs of any clinical trial. Pathway was thoughtfully designed to deliver the highest quality of clinical data, streamline site processes, and improve patient experience.

BAC App
A user-friendly Electronic Cognitive Assessment Battery with improved sensitivity to impairment, the tablet-based BAC App is quick and easy to administer while preserving the psychometric rigor of traditional neurocognitive testing. This provides investigators with meaningful results while reducing rater and patient burden.

The Virtual Reality Functional Capacity Assessment Tool (VRFCAT)
VRFCAT is a computer-based test that simulates instrumental activities of daily living (iADLS) in a realistic and interactive virtual environment. With demonstrated sensitivity to basic functional capacity deficits, the VRFCAT was developed to improve clinical trials by detecting functionally meaningful improvements in patients’ everyday lives. The VRFCAT has numerous advantages over conventional assessments, and meets the highest psychometric and regulatory standards, with strong support from industry sponsors, NIH, and FDA as a functional co-primary outcome measure.

Clinical Trial Services

Expert Data Management – NCT’s expert reviewers identify administration inconsistencies and provide central scoring for a wide range of clinical and cognitive assessments, with rapid turnaround that ensures a clean dataset in real time.

Site Services – From site selection to rater training and data review, NCT knows how to support site performance and high quality data collection.

Measures and Scales – NCT offers a Functional Service Provider (FSP) model for sponsors looking to outsource their scale management needs, leveraging their expertise and established network with test publishers, copyright holders, and scale authors.

Consulting – NCT’s science team is ready and able to help guide your drug development program to meet its scientific and regulatory objectives.

Biostatistics – NCT offers comprehensive statistical services to improve the quality of all phases of clinical research. The company leverages the exceptional scientific depth of its Biostatistics and Leadership teams to ensure that clinical trials are equipped with the best experimental design and statistical methodologies to meet their objectives.

Translations – NCT Linguistics is dedicated to ensuring the highest level of translation services delivered at the pace to support global clinical trials. Launched in 2016 as a division of NeuroCog Trials, NCT Linguistics provides translation, interpretation, and training services in over 150 languages, supported by more than 1,500 certified linguists worldwide.

Therapeutic Areas

NCT has exceptional scientific depth and clinical expertise across many therapeutic areas. The company’s science team has published widely in the CNS field and beyond, and its advisors represent some of the best minds in medicine.

Alzheimer’s Disease and Mild Cognitive Impairment – NCT has reviewed over 20,000 assessments and trained over 2,000 raters for global AD clinical trials.

Severe Mental Illness – NCT’s global leadership in schizophrenia is well known throughout industry and academia. The company also supports clinical development programs in bipolar disorder, major depressive disorder, post-traumatic stress disorder, attention-deficit disorder, and other conditions affecting mental health and cognition.

Movement and Motor Neuron Disorders – NCT has research expertise in Parkinson’s disease (PD), Multiple Sclerosis (MS), Amyotrophic Lateral Sclerosis (ALS), and other neurodegenerative conditions.

Additional Therapeutic Areas – NCT has worked with many other clinical populations to evaluate the cognitive effects of new treatments, including Brain Cancer, Chronic Kidney Disease, and Orphan Diseases.

Leadership

Richard Keefe, PhD, Co-Founder and CEO
Dr. Richard Keefe co-founded NeuroCog Trials in an effort to bring transformative, scientifically rigorous innovation to neurocognitive data collection in clinical trials. He has over 25 years of experience in clinical psychology, neuroscience, and drug development, and is globally recognized for his expertise in novel strategies for measuring human cognition. In addition to his role at NeuroCog Trials, Dr. Keefe is Professor of Psychiatry, Psychology and Neurosciences at Duke University Medical Center, Associate Editor of Psychological Medicine, and serves on the Editorial Board of Schizophrenia Bulletin, Schizophrenia Research, and Innovations in Clinical Neuroscience. He has published over 200 peer-reviewed scientific papers on cognition and CNS disorders.

Caren Gadigian, Co-Founder and President
Caren Gadigian co-founded NeuroCog Trials in 2004, bringing her extensive knowledge of finance and business to spearhead the company’s successful development and rapid expansion. She has over 20 years of experience working with private equity firms, providing investment management and operational expertise across a variety of industry sectors. As President, Ms. Gadigian is responsible for leading the company’s strategic growth and directing the standard of excellence that defines all company operations.

Learn more about NCT’s Leadership Team.

 

For more information or to further discuss your study needs please contact:
Bobbie Theodore, M.S.
Alliance Director
(o) (916) 939-6696
(c) (916) 803-7149
bobbie@alliancesites.com