- Serial PK, PD sampling
- Continuous ECG
- EEG, qEEG, evoked potentials on site
- TQT, QTc, telemetry, holter and ambulatory monitoring
- PET, MRI, and CT scans; 64-slice CT, functional magnetic resonance imaging (fMRI), fiber tracking with the GE Signa HDx 3.0 Tesla MRI, and whole body imaging
- Lumbar puncture and continuous CSF collection on site
- Oral, IV infusion, transdermal patch, sublingual, inhalation and device delivery methods
- Adaptive, umbrella and crossover study designs – healthy and patient populations
- Bioequivalence
- Bioavailability
- Single and multiple ascending dose, sequential and parallel cohorts
- Sequential and parallel cohorts
- Fed and fasted, drug interaction, food effect, safety, efficacy and tolerability
- DEA licensed investigators experienced with managing opiate drugs in clinical trials
